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For patients with severe symptoms, treatment starts with 1000 mcg injected intramuscularly once daily for 7 days, then the frequency can vary to 1-3 times weekly for 4-8 weeks

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Strong appetite suppression, better compliance in calorie deficits, and even potential benefits for body composition and motivation

Since these guidelines are preliminary, researchers should conduct initial dose-finding studies to identify the optimal range for their specific models